In the abstract, it might be tempting to imagine that irreducible complexity simply requires multiple simultaneous mutations - that evolution might be far chancier than we thought, but still possible. Such an appeal to brute luck can never be refuted... Luck is metaphysical speculation; scientific explanations invoke causes.

Michael J. Behe
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As a young biologist, I was constantly frustrated by the fact that most of my colleagues believed in the notion of “irreducible complexity.” A theory that states that complex biological systems can never be produced by random chance. A theory that, depending on the definition is very appealing to biologists, but it is not science. It is nothing more than a metaphysical speculation, an appeal to luck. There are plenty of examples of evolution at work in nature, so it is not necessary to invoke mere chance out of hand.

Source: Darwins Black Box: The Biochemical Challenge To Evolution

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